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ANti-tick vaccines to prevent TIck-borne Diseases in Europe

ANTIDotE is a consortium of 7 European research institutes funded by the European Commssion to investigate anti-tick vaccines. Our objective is to identify and characterize tick salivary gland proteins involved in tick feeding and tick-borne pathogen transmission, and to use this knowledge to develop and assess anti-tick vaccines to prevent multiple human tick-borne diseases.

Press release

Targeting the tick

24 February 2014 , by Gary Finnegan

Understanding the bloodsucking feeding mechanisms of ticks could result in vaccines against hard-to-treat diseases like Lyme disease.

A sneeze, a cough, a kiss – even a handshake: diseases such as measles, whooping cough and the flu are often passed directly from one person to another in tiny droplets of fluid which contain viruses or bacteria. However, not all infectious diseases are spread so directly. Some hijack bloodthirsty insects and arachnids, taking the opportunity to infect humans during feeding time. One such disease risk is the humble tick – an eight-legged parasite often found in Europe’s forests.

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Press release

Amsterdam, August 12th 2013

Three million Euro’s for a vaccine against ticks

The AMC, in collaboration with six European partners, will investigate a vaccine against ticks. This vaccine has to prevent multiple tick-borne diseases. The three million Euro’s, funded by the European Commission as part of the FP7 Work Program, will be divided over the consortium.

Lyme disease, tick-borne encephalitis (TBEV) and human babesiosis are all serious human tick-borne diseases that are more and more frequently encountered in Europe. Against most tick-borne diseases there is no vaccine. That is the reason why the consortium, with the AMC as the coordinator, will investigate a vaccine directed against the tick, rather than different vaccines targeting the individual tick-borne pathogens. Thus, a single vaccine could prevent transmission of multiple pathogens from the tick to the host.

The project is named ANTIDotE – ANti-tick vaccines to prevent TIck-borne Diseases in Europe – and will start in December 2013. The consortium consists of European experts in the field of Lyme disease, TBEV and babesiosis and anti-tick vaccines. The participants are the Dutch National Institute for Public Health and Environment (The Netherlands), Institute of Parasitology, Biology Center at the Academy of Sciences of the Czech Republic (Czech Republic), Free University of Berlin (Germany), Center for Cooperative research in Biosciences (Spain), the small medium-sized enterprise GenXPro (Germany) and the Institute of Virology of the Slovak Academy of Sciences (Slovak Republic).